Touted as the most expensive Japanese anime thriller ever created, this futuristic extravaganza features vibrant computer generated graphics, special effects and vividly drawn comic-book style characters give the film a surreal look. The story is set in the early 21st century. Tokyo has become a megalopolis and a computer network has created a world without borders. The yakuza run rampant and to stop them, the government has devised special cyborg agents out of pieces of human brains, and electronic parts. These machines can then download information at any point in the city. Beautiful Major Kusangi is one such agent. Though built like a beauty queen, inside she is all machine, but for a few hunks of organic brain matter. Still those biological parts are enough to start an identity crisis within. Still she has a job to do and that is to locate Project 2501, a powerful but formless virtual reality creature designed to access any system. The Project, code named "Puppet Master" has become independently intelligent and decides that it is a self-determined life form, beholden to no one. As he goes off in search of a suitable host body, Kusangi pursues him.